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本实验采用放射自显影技术与细胞电生理学方法发现：大鼠脊髓腰膨大部含有较高密度能与（１２５）Ⅰ－胰高血糖素发生特异性结合的受体，其在脊髓内的分布以脊髓背角尤其是背角边缘区和胶质区的受体含量最为丰富；背髓背角内直接注射胰高血糖素（５～１５μｇ）可明显兴奋脊髓内伤害性反应神经元的细胞放电（１２／２２），而对少数伤害性反应神经元（４／２２）和伤害性抑制性反应神经元的放电活动则产生或加深其抑制作用；而这些对胰高血糖素产生兴奋或抑制反应的神经元亦主要位于脊髓背角，并以背角边缘区和胶质区的细胞数量为多。提示大鼠脊髓内不仅含有胰高血糖素的受体，而且还可能参与了脊髓内多种功能尤其是感觉功能的调节。
In this study, autoradiography and electrophysiological methods were used to find that most of the lumbar spine of the rat spinal cord contained a high density of receptors that specifically bound to (125) I-glucagon and its distribution in the spinal cord The spinal cord dorsal horn especially the dorsal horn marginal zone and glial zone receptor content is most abundant; injection of glucagon (5 ~ 15μg) directly into the dorsal horn can significantly excite the cell discharge of nociceptive neurons in the spinal cord 12/22), while the discharge activity of a few nociceptive response neurons (4/22) and nociceptive suppressor neurons produced or deepened their inhibitory effect; whereas these effects of excitatory or inhibitory responses to glucagon Neurons are also predominantly located in the dorsal horn of the spinal cord, with more cells in the dorsal horn margins and glial regions. Prompted that the rat spinal cord contains not only glucagon receptors, but also may be involved in a variety of spinal cord function, especially the regulation of sensory function.