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蛋白质磷酸化是蛋白质翻译后最普遍、最重要的修饰之一,是生物体内一种普通的调节方式,参与调控细胞增殖、信号转导、新陈代谢、肿瘤发生等分子机能,并在精子信号转导和酶合成表达的过程中起重要作用。对精子磷酸化蛋白的研究有助于深入了解精子发生、运输、获能,以及精卵识别的调控机理。因此,在磷酸化蛋白组学的层面上研究精子的各项机能可以为雄性不育更深层的研究提供一条新的道路。
Protein phosphorylation is one of the most common and important modifications after protein translation. It is a common regulation in the organism and is involved in the regulation of molecular functions such as cell proliferation, signal transduction, metabolism, tumorigenesis, and in the process of sperm signal transduction And enzyme synthesis plays an important role in the process of expression. Research on sperm phosphoproteins helps to gain insight into the regulatory mechanisms of spermatogenesis, transport, capacitation, and sperm-egg recognition. Therefore, studying the function of sperm at the level of phosphoproteomics can provide a new way for deeper research on male sterility.