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目的检测P33ING1、Survivin和Ki67蛋白在食管正常黏膜、单纯增生、不典型增生、浸润癌中的表达情况,分析这三种蛋白在食管癌不同病变区域中的表达及与食管癌病理特征的关系。方法采用免疫组化方法检测P33ING1、Survivin和Ki67蛋白在51例食管癌大体标本中的不同病变区域的表达。结果P33ING1蛋白从正常黏膜、单纯增生、不典型增生增生、浸润癌呈渐进性低表达,而Survivin和Ki67蛋白则呈渐进性高表达。三种蛋白在正常黏膜中的表达与不典型增生及浸润癌中的表达差异有显著性(P<0.01);P33ING1蛋白在食管癌中的表达与癌肿浸润深度(肌层至全层)呈负相关(P<0.05),与分化程度(G1、G3)呈正相关(P<0.05);Survivin蛋白表达与食管癌分化程度、淋巴结转移有关(P<0.05);P33ING1蛋白在浸润癌中的低表达与Survivin和Ki67蛋白高表达呈负相关(P<0.01)。结论Survivin功能的激活、Ki67增殖及P33ING1功能的下调可能共同对抗细胞凋亡,参与食管癌的发生发展。三者有可能为临床上食管癌早期诊断、相关治疗及预后研究提供新的手段。
Objective To detect the expression of P33ING1, Survivin and Ki67 in normal esophageal mucosa, simple hyperplasia, atypical hyperplasia and invasive carcinoma, and to analyze the relationship between the expression of these three proteins in esophageal carcinoma and their pathological features. Methods Immunohistochemistry was used to detect the expression of P33ING1, Survivin and Ki67 in 51 different lesions of esophageal cancer specimens. Results P33ING1 protein gradually decreased from normal mucosa, simple hyperplasia, atypical hyperplasia and invasive carcinoma, while Survivin and Ki67 protein showed progressive high expression. The expression of P33ING1 protein in esophageal cancer and the depth of invasion of the tumor (myometrium to the whole layer) were significantly higher than those in the normal mucosa (P <0.01) (P <0.05). There was a positive correlation between the expression of Survivin protein and the degree of differentiation of esophageal cancer and lymph node metastasis (P <0.05). The positive rate of P33ING1 protein in invasive carcinoma The expression was negatively correlated with the high expression of Survivin and Ki67 (P <0.01). Conclusion The activation of Survivin, the proliferation of Ki67 and the down-regulation of P33ING1 function may jointly resist apoptosis and participate in the development of esophageal cancer. All three may provide a new method for clinical diagnosis of esophageal cancer, related treatment and prognosis.