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目的探讨精确选择子宫动脉介入治疗宫颈癌的临床疗效。方法对经病理、细胞学证实为子宫颈癌的84例患者进行造影了解血管情况,然后通过双侧子宫动脉应用顺铂(DDP)、吡柔比星(THP)、丝裂霉素(MMC)、5-氟尿嘧啶(5-FU)中的二联至三联灌注化疗,精确选择子宫动脉采用碘油乳剂和明胶海绵栓塞。13例介入治疗后行根治术。结果 84例均行双侧子宫动脉栓塞,术中造影显示子宫动脉明显增粗,肿瘤滋养血管呈螺旋状,本组治疗总有效率为90.5%。13例术后2周行子宫根治术+盆腔淋巴结清扫术,术中出血量减少,手术时间缩短。主要不良反应为恶心、呕吐、腹痛、发热及白细胞下降。结论精确选择子宫动脉化疗栓塞治疗宫颈癌是安全有效的辅助治疗方法,不良反应少。
Objective To investigate the clinical efficacy of precise choice of uterine artery interventional treatment of cervical cancer. Methods Eighty-four patients diagnosed as cervical cancer by pathology and cytology were enrolled in the study to understand the vascular condition. DDP, THP and MMC were applied to bilateral uterine arteries. , 5-fluorouracil (5-FU) in two to three infusion chemotherapy, the precise choice of uterine artery using lipiodol emulsion and gelatin sponge embolization. Thirteen patients underwent radical surgery after interventional therapy. Results Eighty-four cases underwent bilateral uterine artery embolization. Intraoperative angiography showed that the uterine artery was significantly thicker and the tumor nourished vessels were spirally wound. The total effective rate in this group was 90.5%. Thirteen patients underwent radical hysterectomy and pelvic lymphadenectomy 2 weeks after operation, the amount of bleeding during operation was reduced and the operation time was shortened. The main adverse reactions were nausea, vomiting, abdominal pain, fever and leukopenia. Conclusion Precise choice of uterine artery chemoembolization in the treatment of cervical cancer is a safe and effective adjuvant therapy with less adverse reactions.