最近,在一部分难治性贫血病例中查明有第5号染色体长臂缺失,称为5q-综合征。5q-综合征最初是Van Den Berghe等报告的,随后Mahmood等发现6例。其临床血液学特征是:都有轻度到中度贫血,血色素8.6g/dl～11.1g/dl,血涂片中红细胞的大小显著不同并有变形,可见椭圆红细胞。另外,6例中都有网织红细胞,这提示在本病有效红细胞产生能力是低下的。白细胞数除1例都在正常范围,形态也未见异常。血小板数有增加的倾向,达38.5～64.5万/mm~3。血涂片标本中可见巨大血小板。无异常血红蛋白,血清胆红素、结合球蛋白和LDH值都正常。用~(61)Cr法研究了二例红 Recently, a long arm of chromosome 5 was identified as a 5q-syndrome in some cases of refractory anemia. 5q-syndrome was first reported by Van Den Berghe et al. Then Mahmood et al found 6 cases. The clinical hematological characteristics are: mild to moderate anemia, hemoglobin 8.6g / dl ~ 11.1g / dl, blood smears in the size of red blood cells significantly different and deformed, showing oval red blood cells. In addition, reticulocytes were present in all 6 cases, suggesting that erythrocyte production is ineffective in this condition. In addition to a white blood cell count in the normal range, no abnormalities in morphology. Platelet number tends to increase, reaching 38.5 to 645,000 / mm ~ 3. Blood smear specimens showed huge platelets. No abnormal hemoglobin, serum bilirubin, binding globulin and LDH values ​​are normal. Two cases of red were studied by ~ (61) Cr method