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目的观察乳增胶囊对大鼠乳腺增生的影响。方法选用健康大鼠60只,随机分为6组,每组10只,分别为空白对照组、模型对照组、阳性对照组(乳增宁组)和乳增胶囊高、中、低剂量组,除空白对照组外,其余各组每鼠肌肉注射苯甲酸雌二醇0.5 mg/kg1,次/d,连续40 d,继而改用肌肉注射黄体酮4 mg/kg,1次/d,连续10 d。造模完成后,各组分别灌胃给药,空白对照组和模型对照组灌服蒸馏水,给药量均为10 mL/kg。1次/d,连续给药4 W。结果高中剂量组大鼠乳腺直径,平均腺泡数、腺泡的平均直径及腺腔内分泌物与模型对照组比较有明显改善。结论乳增胶囊能明显著改善大鼠乳腺增生的病理状况。
Objective To observe the effect of Ruzeng Capsule on mammary gland hyperplasia in rats. Methods Sixty healthy rats were randomly divided into 6 groups with 10 rats in each group, which were blank control group, model control group, positive control group (Ruzengning group) and Ruzeng capsule high, medium and low dose group, Except for the blank control group, the mice in each group were intramuscularly injected with estradiol benzoate 0.5 mg / kg once a day for 40 days, then switched to intramuscular injection of progesterone 4 mg / kg once a day for 10 consecutive days d. After modeling, each group was given gavage, blank control group and model control group were fed distilled water, the dosage was 10 mL / kg. 1 / d, continuous administration of 4W. Results In high school, the diameter of mammary gland, the average number of acini, the average diameter of acinus and the secretion of glandular cavity were significantly improved compared with the model control group. Conclusion Ruzeng capsule can significantly improve the pathological conditions of rat mammary gland hyperplasia.