高渗盐水已被作为一种新的治疗颅内高压及脑水肿的手段。数项动物实验揭示,高渗盐水对脑血流、颅内压(ICP)和脑组织水含量有良好效果。本研究采用前瞻性数据库中接受侵袭性ICP监护的病人,均经中心静脉导管滴注3％高渗盐水/醋酸盐溶液,速率范围为75～150ml/h,旨在增加血钠浓度,使之保持在145～155mmol/L,每小时检测血钠、钾一次,每天至少一次生 Hypertonic saline has been used as a new means of treatment of intracranial hypertension and cerebral edema. Several animal experiments revealed that hypertonic saline has good effects on cerebral blood flow, intracranial pressure (ICP) and brain tissue water content. In this prospective database, patients undergoing invasive ICP monitoring were infused with 3% hypertonic saline / acetate solution through a central venous catheter at a rate ranging from 75 to 150 ml / h in order to increase serum sodium concentration Kept at 145 ~ 155mmol / L, hourly test serum sodium, potassium once, at least once a day