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宫颈癌是妇科常见的恶性肿癌之一,而慢性宫颈炎是宫颈癌的高危因素。研究表明,人巨细胞病毒(Human cytomegalovirus,HCMV)感染与宫颈癌的发生有关。并已从宫颈癌组织中鉴定出了C-myc癌基因。为了探讨HCMV感染与C-myc癌基因表达的关系,本文应用核酸杂交技术对87例慢性宫颈炎患者的宫颈活检组织进行了HCMVDNA序列和C-myc癌基因序列的检测。结果87例慢性宫颈炎患者宫颈活检组织中HCMV检出率为11％(10/87),C-myc癌基因的检出率为12％(11/87)。HCMV DNA序列阳性标本中同时C-myc癌基因阳性者有5例(5/10),77例HCMV DNA序列阳性患者中,有6例(6/77),C-myc癌基因阳性。结果提示,HCMV感染对C-myc癌基因表达可能起活化作用。
Cervical cancer is one of the common gynecological cancer, and chronic cervicitis is a high risk factor for cervical cancer. Studies have shown that human cytomegalovirus (HCMV) infection and the occurrence of cervical cancer. The C-myc oncogene has been identified from cervical cancer tissue. In order to investigate the relationship between HCMV infection and C-myc oncogene expression, HCMVDNA and C-myc oncogene sequences were detected in 87 patients with chronic cervicitis by nucleic acid hybridization. Results The positive rate of HCMV in cervical biopsies from 87 patients with chronic cervicitis was 11% (10/87), and the positive rate of C-myc oncogene was 12% (11/87). There were 5 (5/10) positive C-myc oncogene positives in HCMV DNA sequence-positive specimens and 6 (6/77) in 77 HCMV DNA sequence positive specimens. The C-myc oncogene was positive. The results suggest that HCMV infection may activate C-myc oncogene expression.