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华赠素是中华大蟾蛛全皮提取的水溶性制剂，临床和药理研究皆证明它对HBV复制有一定的抑制作用。但其对体外肝细胞损伤及肝细胞纤维化的实验研究尚未见报道，基于此，我们采用体外大鼠肝细胞CC14中毒模型及小鼠胚胎纤维母细胞来研究华蟾素的上述作用。1材料与方法1．1材料：SD?
Huajinsu is a water-soluble preparation extracted from the whole skin of Chinese giant salamander, and both clinical and pharmacological studies have demonstrated that it has a certain inhibitory effect on HBV replication. However, its experimental studies on hepatocyte injury and hepatocyte fibrosis in vitro have not been reported. Based on this, we used the CC14 poisoning model of rat hepatocytes in vitro and mouse embryonic fibroblasts to study the above-mentioned effects of cinobufacini. 1 Materials and Methods 1.1 Materials: SD?