Hemostatic Effect of Chitosan-based Fiber

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Abstract [Objective] The aim was to investigate the hemostatic effects of chitosan- based fibre on liver. [Method] The liver hemorrhage model of rabbit was established. Hemostasis was performed with chitosam-based fiber in experimental group, surgicel in control group and no material in blank group. The hemostatic effects were evalu- ated by total blood loss (TBL) and hemostatic rate. [Result] Experimental group had no bleeding in observation period, with the hemostatic rate of 100% and the blood loss of only (0.443_+0.30) g/kg, better than the control group and blank group (P〈 0.005). [Conclusion] Chitosan-based fiber has effective hemostasis in liver wound, which will provide reliable information for the clinical trials.
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