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纳米材料和纳米科技已经被广泛应用于生物学和生物医学等领域.有研究表明,许多纳米材料具有抗菌特性,然而这些研究主要针对纳米材料对有害病原菌在体外生长的抑制作用,而针对纳米材料在体内对肠道共生菌的作用研究较少.本实验表明,纳米二氧化硅(Si O2)能够在体外抑制肠道共生菌的生长,而同样剂量的纳米Si O2在果蝇体内的环境中对肠道共生菌的生长没有影响;在体外不影响肠道共生菌的纳米金刚石在体内也未表现出对肠道共生菌的影响.因此,纳米材料在体内与体外有可能对肠道共生菌产生不同的效应.相比体外环境,肠道可以为共生菌提供更好的生长环境,保护肠道共生菌免受外来纳米材料的影响.
Nanomaterials and nanotechnology have been widely used in the fields of biology and biomedicine, etc. Many studies have shown that many nanomaterials have antibacterial properties. However, these studies mainly focus on the inhibitory effect of nanomaterials on the growth of harmful pathogens in vitro, There is less research on the role of gut symbionts in vivo.This experiment shows that Si O2 can inhibit the growth of gut symbionts in vitro and the same dosage of nanosized Si O2 in the environment of fruit flies Has no effect on the growth of intestinal commensal bacteria; nanocrystalline diamond that does not affect intestinal commensal bacteria in vitro also shows no effect on intestinal commensal bacteria in vivo, therefore, it is possible for nanomaterials to inhibit intestinal commensal bacteria in vitro and in vivo Produce different effects.Compared with the in vitro environment, the intestine can provide a better growth environment for the commensal bacteria and protect the intestinal commensal bacteria from the external nanomaterials.