论文部分内容阅读
目的:研究宫颈鳞癌组织中细胞间粘附分子(intercellular cell adhesion molecule,ICAM)-3的表达及意义。方法:采用免疫组织化学S-P法检测45例宫颈鳞癌组织、30例宫颈上皮内瘤变(Cervical Intraepithelial Neoplasm,CIN)组织及15例宫颈正常组织中ICAM-3蛋白的表达,分析ICAM-3在不同宫颈组织中的表达情况以及ICAM-3与宫颈鳞癌患者临床分期、肿瘤直径、组织学分级及淋巴结转移的关系。结果:宫颈鳞癌组织中ICAM-3阳性表达率为71.1%(32/45),显著高于其在正常宫颈组织中的阳性表达率6.0%(1/15)及在CINⅡ~Ⅲ组中的阳性表达率40.0%(12/30);ICAM-3在有淋巴结转移组阳性表达率为87.0%(20/23),高于无淋巴结转移组54.5%(12/22);在不同分化程度的癌组织中其阳性率也有一定差异,Ⅰ级与Ⅱ、Ⅲ级之间差异有统计学意义(P<0.05)。结论:ICAM-3蛋白高表达与宫颈鳞癌的发生、发展密切相关。
Objective: To study the expression of intercellular cell adhesion molecule (ICAM) -3 in cervical squamous cell carcinoma and its significance. Methods: Immunohistochemical SP method was used to detect the expression of ICAM-3 protein in 45 cases of cervical squamous cell carcinoma, 30 cases of cervical intraepithelial neoplasm (CIN) and 15 cases of cervical normal tissue. Different cervical tissues and the relationship between ICAM-3 and clinical stage, tumor diameter, histological grade and lymph node metastasis in patients with cervical squamous cell carcinoma. Results: The positive rate of ICAM-3 in cervical squamous cell carcinoma was 71.1% (32/45), which was significantly higher than that in normal cervix (6.0% (1/15)) and in CINⅡ ~ Ⅲ The positive rate of ICAM-3 expression in lymph node metastasis group was 87.0% (20/23), which was higher than that in non-lymph node metastasis group (54.5%, 12/22) The positive rate of cancerous tissue also had some differences, there was a significant difference between Ⅰ and Ⅱ, Ⅲ grade (P <0.05). Conclusion: The high expression of ICAM-3 protein is closely related to the occurrence and development of cervical squamous cell carcinoma.