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目的 :探讨新生儿窒息并脑损害的血小板参数的变化及临床意义。方法 :对 1999年 5月～ 2 0 0 3年 1月被确诊为新生儿窒息并脑损害 5 0例患儿的血小板数 (PLT)、平均血小板体积 (MPV )及血小板分布宽度 (PDW )进行动态观察 ,并与 3 0例窒息无合并脑损害组及 3 0例正常新生儿对照组比较 ;脑损害组中合并颅内出血组 3 0例血小板参数与无颅内出血组 2 0例作比较。结果 :①新生儿窒息并脑损害组急性期 (出生后第 1天 )较无合并脑损害组及正常新生儿对照组明显降低 (P <0 0 1) ,而MPV和PDW与无脑损害组及正常对照组比较明显增高 ,差异显著 (P <0 0 1)。在恢复期 (生后第 7天 ) ,三组的PLT、MPV和PDW之间的比较均无明显差异 (P >0 0 5 )。②急性期脑损害组中合并颅内出血组PLT较无颅内出血组明显降低 (P <0 0 1) ,而MPV和PDW较无颅内出血组明显增高 (P <0 0 5 )。结论 :血小板参数的动态监测可作为判断窒息的预后及早期颅内出血倾向的一项指标
Objective: To investigate the changes and clinical significance of platelet parameters in neonates with asphyxia and brain damage. Methods: Platelet count (PLT), mean platelet volume (MPV), and platelet distribution width (PDW) were measured in 50 children diagnosed as neonatal asphyxia and brain damage from May 1999 to January 2003 Dynamic observation and compared with 30 cases of asphyxia without brain injury group and 30 normal neonates control group; 30 cases of brain injury group with intracranial hemorrhage 30 platelet parameters compared with no intracranial hemorrhage group 20 cases. Results: ① In acute stage of neonatal asphyxia and brain damage group (on the first day after birth), it was significantly lower than those in the non-combined brain damage group and the normal newborn control group (P <0.01) And normal control group was significantly higher, the difference was significant (P <0.01). During recovery (7 days after birth), there was no significant difference in PLT, MPV and PDW between the three groups (P> 0.05). ② PLT in acute brain injury group with intracranial hemorrhage was significantly lower than that without intracranial hemorrhage (P <0.01), while MPV and PDW were significantly higher than those without intracranial hemorrhage (P <0.05). Conclusion: The dynamic monitoring of platelet parameters can be used as an indicator to judge the prognosis of asphyxia and the tendency of early intracranial hemorrhage