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黄连素(BR)是临床治疗肠道细菌感染的常用药物。1987年我们发现它还有抗血小板作用。现简要报道初步结果如下:以家兔血小板为实验材料,使用发光血小板聚集仪,制备富含血小板血浆及贫含血小板血浆。血小板激活剂有ADP、钙离子载体A23187、花生四烯酸(AA)及胶原。它们在试验系统中的最终浓度依次分别为6.6、3.1μmol/L,1.43mmol/L及6.9mh/L。在本实验条件下BR对血小板变形反应的抑制作用为胶原>A23187>AA>ADP;对血小板聚集反应的抑制作用和对血小板释放ATP的抑制作用均为胶原
Berberine (BR) is a commonly used drug for clinical treatment of intestinal bacterial infections. In 1987 we found that it also has anti-platelet effect. The preliminary results are as follows: Rabbit platelet as experimental material, the use of luminescent platelet aggregation device, the preparation of platelet-rich plasma and platelet-poor plasma. Platelet activators are ADP, calcium ionophore A23187, arachidonic acid (AA), and collagen. Their final concentrations in the assay system were 6.6, 3.1 μmol / L, 1.43 mmol / L and 6.9 mM / L, respectively. Under the experimental conditions, the inhibitory effect of BR on platelet deformation was collagen> A23187> AA> ADP; the inhibitory effect on platelet aggregation and the inhibition of platelet ATP release were collagen