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本文系京、津两地三个医院临床试用卡氮芥的综合材料,共试用90例,有效率分别为15/26、24/45、6/19。作者认为一次大剂量用药不如分次用药疗效好,副作用少而小。卡氮芥作用快但缓解期短,一般在数天至7个月,合并应用脱水剂可能延长缓解期。鉴于上述特点,作者建议可试用于手术前准备,以提高手术切除率,术后使用以预防残余癌细胞增殖。本品与其它烷化剂无交叉耐药,并有协同作用。但有效期短,产品有效期为6个月。
This article is a comprehensive trial of clinical trial card nitrogen mustard in three hospitals in Beijing and Tianjin, a total of 90 trials, the effective rate was 15/26, 24/45, 6/19. The author believes that a large dose of medication is not as effective as a fractional medication, and the side effects are small and small. Carnitine has a fast-acting but short remission period, generally from several days to 7 months, and the combined use of dehydrating agents may extend the remission period. In view of the above characteristics, the author suggests that it can be tried for preoperative preparation to increase the resection rate and postoperatively to prevent the proliferation of residual cancer cells. This product has no cross resistance with other alkylating agents and has a synergistic effect. However, the validity period is short and the product is valid for 6 months.