儿童期最常见的眼内肿瘤——视网膜母细胞瘤(简称RB)可能发生于胚胎细胞,并表现为遗传型或非遗传型。最近有证据提示位于13号染色体长臂1区4带(13q14)的RB易感基因实际上是隐性基因。Knudson提出肿瘤是由两次突变造成的。这个观点被Comings加以发挥,他提出显性遗传的肿瘤可能是由于一对调节或抑 The most common intraocular tumor in childhood, retinoblastoma (abbreviated as RB), may occur in embryonic cells and behave as either hereditary or non-genetic. Recently, there is evidence that the RB susceptibility gene located in region 1 and 4 (13q14) of the long arm of chromosome 13 is actually a recessive gene. Knudson proposed that the tumor was caused by two mutations. This view was exploited by Comings, who proposed that dominantly inherited tumors may be due to a pair of regulation or suppression.