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目的:建立红外光谱法鉴别盐酸二甲双胍片和盐酸乙胺丁醇片的方法。方法:采用红外分光光度法,以乙醇为溶剂,对上述两种片剂的主成分进行提取,氯化钾压片,录制红外光谱图。结果:盐酸二甲双胍片和盐酸乙胺丁醇片乙醇提取物的红外光谱图分别与盐酸二甲双胍对照品和盐酸乙胺丁醇对照品的红外光谱图一致,并与《药品红外光谱集》中相应的对照图谱一致。结论:该方法专属性好,可快速、准确地鉴别上述两种片剂。
Objective: To establish a method of identifying metformin hydrochloride tablets and ethambutol hydrochloride tablets by infrared spectroscopy. Methods: Infrared spectrophotometry was used to extract the main components of the above two kinds of tablets with ethanol as solvent, potassium chloride tabletting and infrared spectrum recording. Results: The IR spectra of metformin hydrochloride tablets and ethambutol hydrochloride tablets were the same as the IR spectra of Metformin Hydrochloride and Ethambutol Hydrochloride standards, respectively, and were consistent with the corresponding Control map consistent. Conclusion: This method is specific and can quickly and accurately identify the above two tablets.