AIM:To verify the prevalence of thyroid autoimmunity(TA) and the possible association between atopy and TA in children affected by skin disease.METHODS:Three hundred and twenty-four children consecutively referred due to skin disease symptoms to our Pediatric Department were enrolled.One hundred and eighty-seven were diagnosed with atopic dermatitis(AD),95 with acute urticaria,40 with chronic urticaria(CU),and 2 with alopecia areata(AA).According to the work-up for atopy,the children were divided into two groups:Atopics and non-atopics.TA was diagnosed by serum thyroid peroxidase autoantibodies and/or thyroglobulin autoantibodies levels more than twice normal values over a period of two months by immunoassay.RESULTS:In all children with skin disease,a significant prevalence of TA in atopies compared with non-atopies(13.67%vs 2.67%,P=0.0016) and a significant association between TA and atopy(OR=5.76,95%CI:1.71-19.35) were observed.These findings were confirmed as significant in children with AD:TA in atopies was 11.5%,while TA in non-atopies was2.7%(P=0.03,OR=4.68,95%CI:1.02-21.38).In addition,atopics with CU showed a significantly higher prevalence of TA(26.9%),but none of the non-atopics showed CU(P=0.0326).On the other hand,atopies with AA showed a 100%(2 out of 2) prevalence of TA,compared with none of the non-atopies.CONCLUSION:In children with skin disease,atopy seems to be associated with an increased risk of TA. AIM: To verify the prevalence of thyroid autoimmunity (TA) and the possible association between atopy and TA in children affected by skin disease. METHHODS: Three hundred and twenty-four children consecutively referred due to to disease disease to our Pediatric Department were enrolled. One hundred and eighty-seven were diagnosed with atopic dermatitis (AD), 95 with acute urticaria, 40 with chronic urticaria (CU), and 2 with alopecia areata (AA). Accredited to the work-up for atopy, the children were divided into two groups: Atopics and non-atopics. TA was diagnosed by serum thyroid peroxidase autoantibodies and / or thyroglobulin autoantibodies levels more than twice normal values ​​over a period of two months by immunoassay.RESULTS: In all children with skin disease, a significant prevalence of TA in atopies compared with non-atopies (13.67% vs 2.67%, P = 0.0016) and a significant association between TA and atopy (OR = 5.76, 95% CI: 1.71-19.35) were observed. in children with AD: TA in atopies was 11.5% while TA was in non-atopies was 2.7% (P = 0.03, OR = 4.68, 95% CI: 1.02-21.38) .In addition, atopics with CU showed a significantly higher prevalence of TA (26.9%), none of the non-atopics showed CU (P = 0.0326) .On the other hand, atopies with AA showed a 100% (2 out of 2) prevalence of TA, compared with none of the non- atopies.CONCLUSION: In children with skin disease, atopy seems to be associated with an increased risk of TA.