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目的探讨遗传性子宫内膜癌的发病特点,为遗传性子宫内膜癌的筛查、预防及诊治提供临床依据。方法回顾性分析我院收治的同一家系两代4例子宫内膜癌患者的临床病理资料。结果同一家系两代子宫内膜癌患者共4例,先证者因阴道不规则出血就诊,4年后该家族另外3人(其母、两个妹妹)于同一年内先后发现子宫内膜癌,4例患者发病年龄44~75岁,平均52.3岁。其母亲发病在绝经后,三姐妹发病均在绝经前。三姐妹中2例因不规则阴道出血就诊,1例体检时发现子宫内膜癌就诊,其母亲因绝经后不规则阴道出血就诊。4例患者均在术前诊刮病理检查即发现子宫内膜癌;所有患者均进行了手术+化疗治疗,术后均恢复良好,随访至今均全部存活,未发现复发。结论遗传性子宫内膜癌发病时间早、发病率较高,早发现及早治疗预后较好。
Objective To investigate the incidence of hereditary endometrial cancer and provide a clinical basis for the screening, prevention and treatment of hereditary endometrial cancer. Methods The clinical data of 4 patients with endometrial carcinoma in two generations of the same family treated in our hospital were retrospectively analyzed. Results A total of 4 patients with the same family two generations of endometrial cancer, probands due to irregular vaginal bleeding treatment, 4 years after the other three families (their mother, two sisters) in the same year have found that endometrial cancer, 4 patients aged 44 to 75 years old, average 52.3 years old. The incidence of their mothers after menopause, the three sisters are pre-menopausal onset. Three sisters in 2 cases due to irregular vaginal bleeding clinic, 1 case of physical examination found that endometrial cancer treatment, the mother due to irregular vaginal bleeding after treatment. All 4 patients underwent preoperative curettage and pathological examinations to find endometrial cancer. All patients underwent operation + chemotherapy and recovered well after operation. All patients survived till now and no recurrence was found. Conclusion The incidence of hereditary endometrial cancer is earlier and the incidence rate is higher. Early detection and early treatment have a good prognosis.