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目的研究母细胞性浆细胞样树突细胞肿瘤(BPDCN)的临床病理特点、免疫组化、诊断及鉴别诊断。方法报道1例BPDCN,并复习文献总结其临床病理学、免疫组化特征。结果组织形态学表现为肿瘤细胞弥漫分布,中等大小,细胞质少,核不规则,染色质细,核分裂多见,无坏死。免疫组化:肿瘤细胞CD123、CD56、CD43和S-100(+),少数细胞CD4、CD7和TdT(+),CD2、CD3、CD20、CD21、CD34、CD35、CD68、Pax-5、CD99、CD117和MPO(-)。结论 BPDCN是一种少见的淋巴造血系统高度侵袭性肿瘤,预后差,应注意与其他淋巴造血系统肿瘤相鉴别。
Objective To study the clinicopathological features, immunohistochemistry, diagnosis and differential diagnosis of somatic cytoplasmic dendritic cell tumor (BPDCN). Methods One case of BPDCN was reported and the literature reviewed its clinical pathology and immunohistochemical features. Results Histomorphology showed diffuse distribution of tumor cells, medium size, less cytoplasm, irregular nuclei, fine chromatin, more common mitosis, and no necrosis. Immunohistochemistry: CD123, CD56, CD43 and S-100 (+), CD4, CD7 and TdT (+), CD2, CD3, CD20, CD21, CD34, CD35, CD68, CD117 and MPO (-). Conclusions BPDCN is a rare highly invasive lymphoid hematopoietic tumor with poor prognosis. It should be distinguished from other lymphatic hematopoietic tumors.