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对15例包括血管扩张剂在内的常规治疗无效的严重充血性心力衰竭住院病人,给予Captopril(巯甲丙脯氨酸)治疗。治疗前心功能Ⅳ级8例、Ⅲ级7例,平均3.53级。经过17～120天治疗取得临床、血液动力学及实验室的明显改善。心排出量增加28%、每搏量增加48%、肺毛细血管嵌顿压降低45%,血胆红素降低1.6±0.6毫克%(P<0.05),肾功能、电解质无显著变化,2/3病例心胸比例缩小。心功能改善为Ⅰ级(7例)、Ⅱ级(7例)、Ⅲ级(1例),平均1.61级。1例治疗88天死于肺栓塞,1例不能长期耐受中止治疗,其余病例均治疗至今疗效持续稳定。
Fifteen inpatients with severe congestive heart failure, including conventional vasodilators, including vasodilators, were treated with Captopril (captopril). Pretreatment heart function Ⅳ grade 8 cases, Ⅲ grade 7 cases, an average of 3.53. After 17 to 120 days of treatment to obtain clinical, hemodynamic and laboratory significant improvement. The cardiac output increased by 28%, the stroke volume increased by 48%, pulmonary capillary occlusion pressure decreased by 45%, blood bilirubin decreased by 1.6 ± 0.6 mg% (P <0.05), renal function and electrolyte did not change significantly, 3 cases reduced the proportion of mind. Heart function improved to grade Ⅰ (7 cases), grade Ⅱ (7 cases), grade Ⅲ (1 case), an average of 1.61. One patient died of PE in 88 days and one patient could not tolerate long-term treatment. The rest of the patients were treated till now with stable and stable efficacy.