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目的:观察正常成年猕猴背根神经节神经元型一氧化氮合酶(nNOS)免疫阳性神经元的分布。方法:ABC免疫细胞化学方法显示nNOS免疫阳性神经元,并用体视方法进行定量分析。结果:猕猴颈、胸、腰各段背根神经节nNOS免疫阳性神经元的分布相似,数量较多,阳性神经元的大小不等,多呈圆形或椭圆形;胞浆着色较深,胞核位于细胞中央,不着色,细胞被神经纤维束分隔成群。nNOS免疫阳性神经元以中型神经元为主,其次为小型神经元,其胞浆呈强阳性染色,细胞直径<50μm,大型神经元较少。颈、胸、腰各段背根神经节nNOS免疫阳性神经元的密度以及阳性细胞与总细胞数的比值均无明显差异。结论:猕猴背根神经节nNOS主要表达在中、小型神经元,提示NO可能主要参与痛觉等浅感觉的传导和调制。
Objective: To observe the distribution of neuronal nitric oxide synthase (nNOS) immunoreactive neurons in dorsal root ganglion of normal adult macaques. Methods: ABC immunocytochemistry showed nNOS immunoreactive neurons and was quantitatively analyzed by stereological methods. Results: The distribution of nNOS immunoreactive neurons in the dorsal root ganglion in the neck, chest and waist of the rhesus macaques was similar with a large number of positive neurons, mostly round or oval; The nucleus is located in the center of the cell, does not stain, and the cells are separated into groups by nerve fiber bundles. The neurons of nNOS positive neurons were mainly medium neurons, followed by small neurons. The positive neurons of nNOS positive cells were stained with strong positive staining. The diameter of neurons was less than 50μm and the number of large neurons was less. There were no significant differences in the density of nNOS positive neurons in the dorsal root ganglia and the ratio of positive cells to total cells in the neck, chest and waist. CONCLUSION: The nNOS of dorsal root ganglion in macaque is mainly expressed in medium and small neurons, suggesting that NO may be mainly involved in the conduction and modulation of light sensations such as pain.