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目的通过抗高血压药物卡托普利及可乐宁治疗，对自发性高血压大鼠（ＳＨＲ）的主动脉平滑肌ＤＮＡ合成速率的影响，探讨药物治疗对大血管的作用。方法雄性ＳＨＲ，１２周龄，体重１３０ｇ～１５０ｇ，４２只随机分为３组，ａ．高血压对照组；ｂ．卡托普利组，给予小剂量卡托普利２０ｍｇ／ｋｇｄ－１；ｃ．可乐宁组，９只，给予可乐宁３０μｇ／ｋｇｄ－１。正常血压对照组ＷＫＹ，雄性８只，体重１５０ｇ～１８０ｇ；实验组给药１２周。观察指标：（１）收缩压（ＳＢＰ）自１２周起每４周一次，至２４周；（２）组织形态学方法观察主动脉壁腔比；（３）ＤＮＡ合成速率测定，蛋白、ＤＮＡ含量及与组织之比的影响。结果卡托普利治疗组和可乐宁治疗组均能明显抑制血压升高，并一定程度减轻血管壁肥厚，卡托普利治疗组ＤＮＡ合成速率显著下降（与ＳＨＲ相比Ｐ＜０．０１），蛋白／组织、ＤＮＡ／组织之比也有明显降低（均比ＳＨＲ降低，Ｐ＜０．０５）。可乐宁治疗组ＤＮＡ合成速率虽有所降低，但与ＳＨＲ相比无统计学差异，其它指标也无明显改变。血压与ＤＮＡ合成速率之间存在相关性ｒ＝０．４１９１．Ｐ＞０．０５。结论可乐宁和小剂量的卡托普利治疗ＳＨＲ，可以明显防止其高血压的发展。卡托普利可以?
Objective To investigate the effect of antihypertensive drugs captopril and clonidine on the DNA synthesis rate of aortic smooth muscle in spontaneously hypertensive rats (SHR) and to explore the effect of drug treatment on the large blood vessels. Methods Male SHR, 12 weeks old, weighing 130g ~ 150g, 42 were randomly divided into three groups, a. Hypertension control group; b. Captopril group, given a small dose of captopril 20mg / kgd-1; c. Cloaken group, n = 9, given clonidine 30μg / kgd-1. Normal blood pressure control group WKY, 8 males, weighing 150g ~ 180g; experimental group for 12 weeks. Observed indicators: (1) systolic blood pressure (SBP) once every 4 weeks from the 12th week to 24 weeks; (2) morphological observation of aortic wall cavity ratio; (3) DNA synthesis rate determination, protein, DNA content And the impact of the ratio of organizations. Results Both captopril and clonidine significantly inhibited the increase of blood pressure and alleviated the vascular wall hypertrophy to a certain degree, and the rate of DNA synthesis in captopril group decreased significantly (P <0.01 compared with SHR group) , Protein / tissue, DNA / tissue ratio also significantly reduced (both lower than SHR, P <0.05). Although the rate of DNA synthesis in the Coleraine treatment group was lower than that in the SHR group, no significant difference was observed in other indexes. There was a correlation between blood pressure and DNA synthesis rate r = 0.4191. P> 0.05. Conclusion Clonidine and low-dose captopril treatment of SHR, can significantly prevent the development of hypertension. Captopril can?