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采用ＡｇＮＯＲ技术对正常口腔粘膜、口腔粘膜乳头状增生、扁平苔藓、乳头状瘤、白斑及口腔鳞癌共４９例进行了ＡｇＮＯＲ计数及大、小ＡｇＮＯＲ颗粒数比值的定量研究。本结果提示：上皮异常增生型白斑具有高度癌变危险性。每个细胞ＡｇＮＯＲ颗粒数均值５（个）似乎作为口腔粘膜良恶性病变的临界值。实验结果表明：结合ＨＥ切片对照观察ＡｇＮＯＲ计数，大、小颗粒比值，对口腔粘膜良恶性病变的鉴别及对增生性病变尤其白斑癌变倾向的预测有重要的临床意义。
In AgNOR technique, 49 cases of normal oral mucosa, oral mucosal papillary hyperplasia, lichen planus, papilloma, leukoplakia and oral squamous cell carcinoma were studied with AgNOR counting and quantitative analysis of AgNOR particle number ratio. The results suggest that: epithelial dysplasia with high risk of malignant leukoplakia. Five (5) AgNOR particles per cell appear to be critical for benign and malignant oral mucosal lesions. The experimental results show that the combination of HE slice control AgNOR count, large and small particles ratio, the identification of benign and malignant lesions of oral mucosa and hyperplastic lesions, especially the prediction of malignant leukoplakia has an important clinical significance.