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目的:探讨埃索美拉唑加左氧氟沙星加阿莫西林三联1周疗法根除幽门螺杆菌(HP)的疗效及安全性。方法:选择84例符合条件的HP阳性慢性胃炎和消化性溃疡患者,随机分为两组。治疗组采用埃索美拉唑(20mg,2次/d)加左氧氟沙星(200mg,2次/d)加阿莫西林(1000mg,2次/d),治疗7d;对照组采用埃索美拉唑(20mg,2次/d)加克拉霉素(250mg,2次/d)加阿莫西林(1000mg,2次/d),治疗7d;疗程结束4周后复查,观察HP根除率及不良反应。结果:治疗组对照组的HP根除率分别为90.69%和84.21%。两组无统计学差异(P>0.05)。结论:埃索美拉唑加左氧氟沙星加阿莫西林三联1周疗法是根除HP的理想方案。
Objective: To investigate the efficacy and safety of esomeprazole plus levofloxacin plus amoxicillin in combination with 1 week therapy for the eradication of Helicobacter pylori (HP). Methods: Eighty-four patients with HP-positive chronic gastritis and peptic ulcer were selected and randomly divided into two groups. The patients in the treatment group were treated with esomeprazole (20 mg twice a day) plus levofloxacin (200 mg twice a day plus amoxicillin (1000 mg twice a day for 7 days, (20mg, twice a day) plus clarithromycin (250mg, twice daily) plus amoxicillin (1000mg twice daily) for 7 days. After 4 weeks of treatment, the eradication rate and adverse reactions . Results: The HP eradication rate in the control group was 90.69% and 84.21% respectively. There was no significant difference between the two groups (P> 0.05). Conclusions: The combination of esomeprazole plus levofloxacin plus amoxicillin for 1 week is ideal for eradication of HP.