本文以单克隆抗体ELISA夹心法对26例慢性活动性乙型肝炎(CAH-B)与40例重症乙型肝炎(SH-B)患者检测了血浆可溶性白细胞介素2受体(sIL-2R).结果提示CAH-B和SH-B患者血浆sIL-2R水平明显高于对照组(P<0.0005),SH-B的sIL-2R水平高于CAH-B(P<0.05);而急性重肝、亚急性重肝与慢性重肝三者之间血浆sIL-2R水平无显著性差异,提示血浆sIL-2R水平高低与肝脏损害严重程度明显相关.HBeAg阳性组与抗-HBe阳性组血浆sIL-2R水平无明显差别(P>0.05),这似乎说明血浆.sIL-2R水平高低与HBV复制状态无关. In this study, 26 patients with chronic active hepatitis B (CAH-B) and 40 patients with severe hepatitis B (SH-B) were assayed for serum soluble interleukin 2 receptor (sIL-2R) (P <0.0005), the level of sIL-2R in SH-B was higher than that in CAH-B (P <0.05), while the acute severe hepatitis , There was no significant difference in plasma sIL-2R levels between sub-acute and chronic severe hepatitis, suggesting that the level of plasma sIL-2R was significantly correlated with the severity of liver damage.HeAg-positive and anti-HBe positive serum sIL- 2R levels did not differ significantly (P> 0.05), which seems to indicate that plasma levels of sIL-2R have nothing to do with the status of HBV replication.