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免疫组化法研究吡格列酮对糖尿病大鼠肾脏基质金属蛋白酶 2、9(MMP 2、9)和Ⅳ型胶原 (C Ⅳ )表达的影响。结果提示 ,吡格列酮治疗可逆转糖尿病大鼠MMP 2的下降 ,降低C Ⅳ的表达 ,从而可能延缓肾纤维化的进展。
The effect of pioglitazone on the expression of matrix metalloproteinase 2, 9 (MMP 2, 9) and collagen Ⅳ (C Ⅳ) in kidney of diabetic rats was studied by immunohistochemistry. The results suggest that pioglitazone can reverse the decline of MMP 2 and decrease the expression of C Ⅳ in diabetic rats, which may delay the progression of renal fibrosis.