论文部分内容阅读
目的分析不同类型冠心病(CHD)患者血清高敏C反应蛋白(hs-CRP)和白细胞介素-6(IL-6)浓度差异,探讨炎症反应及冠状动脉狭窄程度在CHD发生发展中的作用以及两者的相互关系。方法检测30例急性心肌梗死(AMI)患者(AMI组)、30例不稳定型心绞痛患者(UAP组)、30例稳定型心绞痛患者(SAP组)以及60名正常者(对照组)血清hs-CRP、IL-6浓度,并结合冠状动脉狭窄程度分析不同类型CHD患者血清hs-CRP和IL-6浓度差异,对血清hs-CRP、IL-6及冠状动脉病变积分进行相关分析。结果CHD组患者血清hs-CRP、IL-6显著高于对照组[(5.1±2.4)mg/Lvs(2.3±1.2)mg/L、(16±4)ng/Lvs(12±3)ng/L],均P<0.01。AMI组与UAP组间血清hs-CRP、IL-6比较差异均无统计学意义(P>0.05),但均显著高于SAP组(P<0.05),SAP组血清hs-CRP、IL-6均显著高于对照组(P<0.05)。血清hs-CRP与IL-6显著正相关(r=0.55,P<0.01)。血清hs-CRP、IL-6分别与冠状动脉病变积分显著正相关,相关系数分别为0.57和0.43,P值均<0.01。结论不同类型CHD患者炎症反应水平不同,冠状动脉病变越广泛,血清hs-CRP、IL-6水平增高显著,血清hs-CRP、IL-6增高可能是CHD的重要危险因素。
Objective To analyze the difference of serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels in patients with different types of coronary heart disease (CHD) and explore the role of inflammation and coronary artery stenosis in the pathogenesis of CHD The relationship between the two. Methods Thirty patients with acute myocardial infarction (AMI), 30 patients with unstable angina (UAP), 30 patients with stable angina (SAP) and 60 normal subjects (control group) CRP and IL-6 in serum of patients with CHD, and to analyze the difference of serum hs-CRP and IL-6 concentration in patients with different types of CHD according to the degree of coronary stenosis. Correlation analysis was made between serum hs-CRP, IL-6 and coronary artery disease. Results The serum levels of hs-CRP and IL-6 in CHD group were significantly higher than those in control group [(5.1 ± 2.4) mg / L vs (2.3 ± 1.2) mg / L and (16 ± 4) ng / L vs L], all P <0.01. There was no significant difference in serum hs-CRP and IL-6 between AMI group and UAP group (P> 0.05), but both of them were significantly higher than SAP group (P <0.05) Were significantly higher than the control group (P <0.05). Serum hs-CRP was positively correlated with IL-6 (r = 0.55, P <0.01). Serum levels of hs-CRP and IL-6 were significantly and positively correlated with coronary artery disease scores, with correlation coefficients of 0.57 and 0.43, respectively, P <0.01. Conclusion Different types of CHD patients with different levels of inflammatory response, coronary lesions more widely, serum hs-CRP, IL-6 increased significantly, serum hs-CRP, IL-6 increased may be an important risk factor for CHD.