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229例 HBV 感染者,用 ELISA 法检测抗 HCV、HDV—Ag 和抗 HDV。HBV 感染者的 HBV 与 HCV 二重感染率为27.95%;HBV、HDV 二重感染率为8.30%,HBV、HCV、HDV 三重感染率为5.68%。HBV 和 HCV 二重感染者,主要分布于 HCC、HLC,其次为 FHF、AVH。各临床型乙肝患者,HCV 感染率之间有显著性差异(X~2=35.75,P<0.005)。64例 HBV 和 HCV 二重感染者与125例单纯 HBV 感染者 e 抗原比较也有显著性差异(X~2=15.80,P<0.005),表明 HCV 感染似有抑制 HBV 复制,使病程迁延加重的可能。HBV、HCV、HDV 三重感染者与单纯 HBV 感染者 e抗原检出率无差异(P>0.05)。这些结果提示,乙、丙、丁型肝炎重叠感染者比单一感染者预后差,病情重,病程长,重叠感染可能是乙肝慢性化活动性,反复急性发着的主要原因。
229 HBV infected persons were tested for anti-HCV, HDV-Ag and anti-HDV by ELISA. The rate of HBV and HCV infection was 27.95% in HBV infected patients, 8.30% in HBV and HDV, and 5.68% for HBV, HCV and HDV. HBV and HCV double infection, mainly in HCC, HLC, followed by FHF, AVH. There was a significant difference in the prevalence of HCV among all clinical hepatitis B patients (X ~ 2 = 35.75, P <0.005). There were also significant differences (P <0.005) between the 64 patients with HBV and HCV infection and 125 patients with HBV infection alone (X 2 = 15.80, P <0.005), indicating that HCV infection may inhibit the replication of HBV and prolong the duration of HBV infection . There was no difference in the detection rate of e antigen in patients with HBV, HCV, HDV and HBV infection (P> 0.05). These results suggest that patients with hepatitis B, C and D overlap are worse prognosis than those with single infection, with severe illness and long course of disease. Over-infection may be the main reason for the chronic activity of hepatitis B and repeated acute exacerbation.