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为探讨云芝多糖对动脉粥样硬化（ＡＳ）的治疗作用，我们用氧化修饰低密度脂蛋白（Ｏｘ－ＬＤＬ）单克隆抗体检测和硝酸还原酶法观察了冠心病患者血清ＯｘＬＤＬ和ＮＯ含量的变化以及云芝多糖对这些变化的影响，结果显示：（１）冠心病组血清ＯｘＬＤＬ含量显著高于正常对照组（Ｐ＜０．０１），ＮＯ含量显著低于正常对照组（Ｐ<０.０１〕；（２）口服云之多糖３０天后冠心病患者血清ＯｘＬＤＬ含量明显下降（Ｐ＜０．０１）而ＮＯ含量显著升高（Ｐ＜０．０１）。提示云芝多糊４冠心病具有一定的治疗作用。
To investigate the therapeutic effect of PSK on atherosclerosis (AS), we used Ox-LDL monoclonal antibody detection and nitrate reductase method to observe serum OxLDL and NO levels in patients with coronary heart disease. Changes and effects of PSK on these changes showed that: (1) Serum OxLDL levels in the coronary heart disease group were significantly higher than those in the normal control group (P<0.01), and NO levels were significantly lower than those in the normal control group (P<0. 01〕;(2)OxyLDL content in patients with coronary heart disease was significantly decreased (P<0.01) and NO content was significantly increased (P<0.01) after oral administration of Yunzhi polysaccharide for 30 days. A certain therapeutic effect.