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目的:探讨经鼻蝶窦入路垂体腺瘤显微切除术的疗效及安全性。方法:回顾性分析2004年12月至2015年9月于我科进行经鼻蝶窦入路垂体腺瘤切除及经颅入路垂体腺瘤切除术患者的临床资料,随机分为观察组及对照组,比较两组患者的手术情况、疗效及并发症发生情况。结果:观察组患者在手术时间、术中出血量、引流量、下地时间、术后住院时间及全切率等方面均明显优于对照组,差异具有统计学意义(P<0.05)。观察组治愈率为63.1%,对照组为39.7%,观察组明显高于对照组(P<0.05)。观察组术后并发症发生率为15.4%,对照组为39.7%,观察组显著低于对照组(P<0.05)。结论:经鼻蝶窦入路垂体腺瘤显微切除术具有良好的临床疗效,且创伤小,安全性高,值得临床推广应用。
Objective: To investigate the efficacy and safety of microsurgical resection of the pituitary adenoma through the nasal sphenoid sinus. Methods: The clinical data of patients who underwent resection of the pituitary adenomas through transnasal sphenoid sinus surgery and trans-cranial pituitary adenoma resection in our department from December 2004 to September 2015 were retrospectively analyzed. They were randomly divided into observation group and control group Group, comparing the two groups of patients surgery, efficacy and complications. Results: The observation group was significantly better than the control group in the operation time, intraoperative blood loss, drainage volume, time to stay, postoperative hospital stay and total resection rate, the difference was statistically significant (P <0.05). The cure rate was 63.1% in the observation group and 39.7% in the control group, which was significantly higher in the observation group than in the control group (P <0.05). The incidence of postoperative complications was 15.4% in the observation group and 39.7% in the control group, which was significantly lower in the observation group than in the control group (P <0.05). Conclusion: Microsurgical resection of the pituitary adenoma through the nasal sphenoid sinus has good clinical curative effect, small trauma and high safety, which is worthy of clinical application.