论文部分内容阅读
目的分析中枢神经系统感染的临床特点和病原学特征,为提高疾病治疗效果提供依据。方法回顾性分析医院2010年7月-2012年7月收治的中枢神经系统感染患者的临床资料,总结分析中枢神经系统感染患者的临床表现、感染菌病原学特点等。结果入选的199例病例中发生呕吐21例、头痛179例、脑膜刺激征166例,发生率分别为10.5%、89.9%、83.4%;实验室检查中,脑脊液浑浊161例,脑脊液澄清38例,分别占80.9%、19.1%;共培养出227株病原菌,其中革兰阳性菌98株占43.2%,革兰阴性菌121株占53.3%;其他8株占3.5%;表皮葡萄球菌和溶血葡萄球菌对万古霉素、利奈唑胺、替考拉宁和磷霉素等抗菌药物敏感。结论中枢神经系统感染的主要病原菌为革兰阳性菌和革兰阴性菌,应根据药敏试验结果,合理使用抗菌药物,提高临床治疗效果,缩短治疗时间。
Objective To analyze the clinical features and etiological characteristics of central nervous system infection and provide evidence for improving the therapeutic effect of the disease. Methods The clinical data of patients with central nervous system infection admitted from July 2010 to July 2012 in our hospital were retrospectively analyzed. The clinical manifestations, the etiological characteristics of the infected bacteria and so on were analyzed. Results Among the 199 cases selected, 21 cases had vomiting, 179 cases had headache and 166 cases had meningeal irritation. The incidence rate was 10.5%, 89.9% and 83.4% respectively. 161 cases of cerebrospinal fluid turbidity and 38 cases of cerebrospinal fluid clarification were found in laboratory tests. Accounting for 80.9% and 19.1% respectively; 227 strains of pathogens were co-cultivated, of which 98 strains were Gram-positive bacteria, 43.2% Gram-negative bacteria and 121 strains, accounting for 53.3%; the other 8 strains were 3.5%; Staphylococcus epidermidis and Staphylococcus haemolyticus Sensitive to antibacterials such as vancomycin, linezolid, teicoplanin and fosfomycin. Conclusion The main pathogens of CNS infection are Gram-positive bacteria and Gram-negative bacteria. According to the results of drug susceptibility test, antibacterial drugs should be used reasonably to improve the clinical curative effect and shorten the treatment time.