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目的:观察丙型肝炎病毒(HCV)感染者与健康人血清载脂蛋白AⅠ(apoAⅠ)及AⅡ(apoAⅡ)水平的差异.方法:分别取健康人及HCV感染者的血清各75份,其男女比例及各年龄段比例基本相同.平均年龄健康人为44.2岁,HCV感染者为42.6岁.检测血清中的apoAⅠ及apoAⅡ含量,用统计学方法分析其差异.结果:HCV感染者血清中的apoAⅠ的均数测定值为113.0mg/dl,apoAⅡ的均数测定值为22.5mg/dl,其含量均低于健康人血清中的apoAⅠ(均数为124.2mg/dl)及apoAⅡ(均数为24.9mg/dl),P值<0.05,有统计学意义.另外,HCVRNA及抗-HCV均阳性的患者血清中的apoAⅠ(均数为109.2mg/dl)及apoAⅡ(均数为21.1mg/dl)含量均低于抗-HCV阳性,但HCVRNA阴性的患者(其apoAⅠ及apoAⅡ的均数测定值分别为116.8mg/dl及23.3mg/dl),P值>0.05,无统计学意义.结论:感染HCV后,患者血清中apoAⅠ及apoAⅡ的含量有不同程度的下降.而且,HCVRNA阳性的血清中,apoAⅠ及apoAⅡ的含量也有减少的趋势.因标本量较小,在统计学意义上无明显差异.
Objective: To observe the differences of serum apolipoprotein AⅠ (apoAⅠ) and AⅡ (apoAⅡ) levels between hepatitis C virus (HCV) infected and healthy people.Methods 75 healthy volunteers and 75 healthy volunteers were enrolled, The proportion and the proportion of all age groups were basically the same.The average age of healthy people was 44.2 years old and HCV infection was 42.6 years old.Serum levels of apoAⅠ and apoAⅡ were detected by statistical methods.Results: Mean values were 113.0 mg / dl, apoA II mean was 22.5 mg / dl, which were lower than apoAI (mean 124.2 mg / dl) and apoA II (mean 24.9 mg / dl), P value <0.05, in addition, apoAI (mean 109.2 mg / dl) and apoA II (mean 21.1 mg / dl) in sera of patients with positive HCVRNA and anti- Were lower than that of anti-HCV, but the HCVRNA-negative patients (mean apoAⅠ and apoAⅡ were 116.8mg / dl and 23.3mg / dl respectively), P value> 0.05.Conclusion: , The serum levels of apoAⅠ and apoAⅡwere decreased to some extent.Among the HCVRNA-positive serum, the apoAⅠand apoAⅡlevels There is also a decreasing trend. Due to the small sample volume, no significant difference statistically significant.