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目的对陕西地区23种人乳头状瘤病毒(HPV)基因型的分子流行病学特点进行调查,为HPV感染的预防以及宫颈癌的防治提供参考依据。方法采用荧光PCR法对7 904例标本的HPV感染情况及型别分布进行分析。结果 HPV阳性感染率为30.97%,其中高危型感染占总感染的65.65%,常见的高危亚型依次为HPV 52、16、58、53、51、68和18型。5个年龄组中筛查人群以25~44岁患者为主,占65.78%;HPV阳性率以<25岁(36.02%)和≥55岁(33.33%)的年龄较高。HPV感染中,各年龄组均以单重感染居多,占总感染的66.38%。多重感染中,以二重感染最为常见,占多重感染的63.55%。结论陕西地区HPV感染以单重感染为主,高危型优势型别为HPV 52、16、58、53、51、68和18型。
Objective To investigate the molecular epidemiological characteristics of 23 human papillomavirus (HPV) genotypes in Shaanxi Province and provide a reference for the prevention of HPV infection and prevention and treatment of cervical cancer. Methods Fluorescent PCR was used to analyze the HPV infection status and type distribution of 7 904 specimens. Results The positive rate of HPV infection was 30.97%, of which high-risk infection accounted for 65.65% of the total infection. The common high-risk subtypes were HPV types 52, 16, 58, 53, 51, 68 and 18, respectively. Among the five age groups, the screening population was mainly 25-44 years old, accounting for 65.78%. The HPV positive rate was higher for those aged <25 years (36.02%) and ≥55 years (33.33%). In HPV infection, all age groups were mostly single infection, accounting for 66.38% of the total infection. In multiple infections, the most common infection is double infection, accounting for 63.55% of multiple infections. Conclusion HPV infection in Shaanxi Province is dominated by single infection, and the predominant types of high risk type are HPV types 52, 16, 58, 53, 51, 68 and 18.