某些抗生素能诱发凝血缺陷的问题最近引起了争论。根据许多报告认为使用一些较新的β-内酰胺抗生素(主要是Cephamandole、Cefoperazorte、Latamoxef),与凝血酶原过低血症和出血症状有关,因而提出这一问题。这种联系的本身并不新奇。1971年,Ham报道过5例病人在接受氨苄青霉素治疗后,发生凝血酶原过低血症,其中4例发生出血。在这些病例中,凝血功能低下,经维生素K治疗有效。此后,加拿大和美国的一些学者进一步阐 The issue of the ability of certain antibiotics to induce coagulation defects has recently caused controversy. This is posed by many reports that some of the newer β-lactam antibiotics (mainly Cephamandole, Cefoperazorte, Latamoxef) are associated with prothrombin hypohalia and bleeding symptoms. This connection is not new in itself. In 1971, Ham reported that 5 patients developed prothrombin hypohalia after ampicillin treatment, with bleeding in 4 of them. In these cases, hypothyroidism, vitamin K treatment is effective. Since then, some scholars in Canada and the United States have further elaborated