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目的探讨清开颗粒对亚临床肝性脑病(SHE)大鼠神经诱发电位的影响。方法以四氯化碳高脂低蛋白复合因素建立SHE大鼠模型。造模成功后分为治疗组、对照组及模型组,分别给予清开颗粒、乳果糖、生理盐水灌胃;并设正常组。分别于治疗前和治疗2周检测各组大鼠体表感觉诱发电位(SEP)的潜伏期(PL)和听觉诱发电位(AEPs)的PL、波间期(IPL)。结果治疗组大鼠听觉诱发电位Ⅰ波、Ⅲ波PL接近正常组(P>0.05),但明显小于模型组与对照组(P<0.01)。治疗组大鼠听觉诱发电位Ⅰ-Ⅲ、Ⅰ-Ⅴ、Ⅲ-Ⅴ波IPL接近正常组(P>0.05);与模型组比较,Ⅰ-Ⅲ波IPL差异有统计学意义(P<0.01);与对照组比较,Ⅰ-Ⅲ、Ⅰ-Ⅴ、Ⅲ-Ⅴ波的IPL差异无统计学意义(P>0.05)。结论清开颗粒能显著改善SHE大鼠的神经生理功能。
Objective To investigate the effect of Qingkai granules on neurogenic evoked potential in subclinical hepatic encephalopathy (SHE) rats. Methods A SHE rat model was established with the combination of carbon tetrachloride, high fat and low protein. After the model was successfully established, it was divided into treatment group, control group and model group. Qingkai granules, lactulose, and normal saline were given to the stomach; normal groups were set up. The latency (PL) of body surface sensory evoked potential (SEP) and the PL and inter-wave period (IPL) of auditory evoked potentials (AEPs) were measured in each group before and at 2 weeks of treatment. Results The amplitude of auditory evoked potential I wave and III wave PL in the treatment group were similar to those in the normal group (P>0.05), but significantly lower than those in the model group and the control group (P<0.01). The IPL of auditory evoked potential I-III, I-V and III-V waves in the treatment group were similar to those in the normal group (P>0.05). Compared with the model group, the IPL of I-III wave had statistical significance (P<0.01). Compared with the control group, the IPL of I-III, I-V and III-V waves had no significant difference (P>0.05). Conclusion Qingkai granules can significantly improve the neurophysiological function of SHE rats.