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Hepatocellular carcinoma is difficult to treat,primarilybecause the underlying molecular mechanisms drivingclinical outcome are still poorly understood.Growingevidence suggests that the tissue microenvironmenthas a role in the biological behavior of the tumor.Themain clinical issue is to identify the best target fortherapeutic approaches.Here,we discuss the hypothesis that the entire tissue microenvironment might beconsidered as a biological target.However,the tissuemicroenvironment consists of several cellular and biochemical components,each of which displays a distinctbiological activity.We discuss the major components ofthis environment and consider how they may interactto promote tumor/host crosstalk.
Hepatocellular carcinoma is difficult to treat, Pres andbecause the underlying molecular mechanisms drivingclinical outcome are still poorly understood.Growingevidence suggests that the tissue microenvironmenthas a role in the biological behavior of the tumor. The main clinical issue is to identify the best target fortherapeutic approaches. Here, we discuss the hypothesis that the entire tissue microenvironment might beconsidered as a biological target.However, the tissuemicroenvironment consists of several cellular and biochemical components, each of which displays a distinctbiological activity. We discuss the major components ofthis environment and consider how they may interactto promote tumor / host crosstalk.