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应用链霉菌抗生素蛋白－过氧化物酶连接法（ＳＰ免疫组化法）检测１９８０～１９８９年存档的３３例胃癌及癌旁组织石蜡包埋标本的Ｐ５３表达情况，并与临床、病理和随访资料进行对比分析，结果显示：胃癌组织中Ｐ５３蛋白的表达阳性率为３３．３％，而癌旁正常组织中几乎无阳性表达；胃癌组织中Ｐ５３的表达与患者的性别、年龄、肿瘤部位、病理类型、Ｌａｕｒｅｎ＇ｓ分型、肿瘤浸润深度、淋巴结转移、生存年限等无显著相关，提示Ｐ５３基因的改变可能主要发生在癌变的早期，对胃癌的发生起着较为关键的作用，但并不影响胃癌的生物学行为。
Streptavidin antibiotic protein-peroxidase ligation (SP immunohistochemical method) was used to detect the expression of P53 in paraffin-embedded specimens from 33 cases of gastric cancer and paracancerous tissues archived from 1980 to 1989, and was correlated with clinical, pathological and follow-up data. A comparative analysis showed that the positive rate of P53 protein expression in gastric cancer tissues was 33.3%, and there was almost no positive expression in paracancerous normal tissues; the expression of P53 in gastric cancer tissues was correlated with the patient’s gender, age, tumor site, and pathology. There was no significant correlation between type, Lauren’s type, depth of tumor invasion, lymph node metastasis, age of survival, etc., suggesting that the change of P53 gene may occur mainly in the early stage of canceration and play a key role in the occurrence of gastric cancer, but it does not affect The biological behavior of gastric cancer.