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在研制甲硝唑明胶海绵治疗牙周病成功及进一步研究牙周袋和感染根管生态系基础上，利用可吸收高分子多聚物明胶、聚乙烯醇和羟丙基甲基纤维素，通过交网、固化和包膜等理化方法，设计开发适合口腔局部微环境需要的甲硝唑控释药物。实验证明它可直接放入牙周袋和感染根管，针对口腔局部厌氧菌，能在预定48h内持续释放相对恒定的有效甲硝唑浓度，不影响口腔健康部位和胃肠道等处的正常菌群。它有使用药量小、有效、方便和安全等优点，是一种理想的临床用药方法。
Based on the success of metronidazole gelatin sponge in the treatment of periodontal disease and the further study of periodontal pocket and infected root canal ecosystem, using absorbable macromolecular polymer gelatin, polyvinyl alcohol and hydroxypropyl methylcellulose, Network, curing and coating and other physical and chemical methods, design and development of oral micro-environment for the needs of metronidazole controlled-release drugs. Experiments show that it can be placed directly into the periodontal pocket and root canal infection, for oral anaerobic bacteria, can be scheduled within 48h sustained release of a relatively constant effective metronidazole concentration does not affect the oral health and gastrointestinal tract, etc. Normal flora. It is the use of small doses, effective, convenient and safe, it is an ideal clinical medication.