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目的:评估白细胞参数对于妊娠期高血压疾病的预测价值。方法:采用病例对照的方法研究523例妊娠期高血压疾病患者和853例正常妊娠妇女血液系统的白细胞参数,分析其对妊娠期高血压疾病的预测价值。结果:在妊娠中期前,妊娠期高血压疾病患者的白细胞参数比正常对照孕妇明显升高,而在妊娠末期明显低于对照组。妊娠13～20周,嗜中性粒细胞和嗜碱粒细胞的增加对妊娠期高血压疾病预测的OR分别是1.16和1.02(P<0.01)。当嗜中性粒细胞高于6.12×109/L时,灵敏度是71.95%;嗜碱粒细胞高于0.053×109/L时,特异性是71.01%。结论:白细胞参数的改变对妊娠期高血压疾病具有一定的临床预测效率。
OBJECTIVE: To assess the predictive value of leukocyte parameters for gestational hypertension. Methods: The leukocyte parameters of 523 pregnant women with hypertensive disorder complicating pregnancy and 853 normal pregnant women were studied by case-control method. The predictive value of hypertensive disorders in pregnancy was analyzed. Results: Before the second trimester of pregnancy, the parameters of leukocytes in hypertensive disorder complicating pregnancy were significantly higher than those in normal pregnant women and significantly lower in pregnant women at the end of pregnancy. The predicted OR for gestational hypertension among the 13-20 weeks gestation was 1.16 and 1.02, respectively (P <0.01) for neutrophils and basophils. Sensitivity was 71.95% for neutrophils above 6.12 × 109 / L, and 71.01% for neutrophils above 0.053 × 109 / L. Conclusion: The change of leukocyte parameters has certain clinical prediction efficiency on hypertensive disorder complicating pregnancy.