论文部分内容阅读
用二辛可宁酸法测定259例胃病患者胃液巯基肽,结果显示,胃癌组胃液巯基肽显著高于食管癌(P<0.01)、胃炎(P<0.001)和溃疡组(P<0.001)。除5例胃印戒细胞癌均为阴性外,胃液巯基肽诊断胃癌的灵敏度、特异度和准确度分别为83.0％、85.5％和85.0％。比较表明,胃癌前期病变、未分化和低分化腺癌胃液巯基肽含量是中、高分化和印戒细胞癌的2～4倍,而且与胃液唾液酸(GSA)高度相关(r=0.72),提示了胃液巯基肽测定不仅有早期诊断价值而且与胃腺癌分化程度有关,是一种新的诊断胃癌较有价值的非蛋白质标志物。
The citrullinated acid method was used to measure the gastric fluid thiol peptides in 259 patients with gastric diseases. The results showed that the gastric fluid thiol peptide was significantly higher than that of esophageal cancer (P<0.01), gastritis (P<0.001) and ulcer group (P<0.001). Except 5 cases of gastric signet ring cell carcinoma were negative, the sensitivity, specificity and accuracy of gastric fluid thioglycol in the diagnosis of gastric cancer were 83.0%, 85.5% and 85.0%, respectively. The comparison showed that the content of thioglycol in the gastric juice of precancerous lesions, undifferentiated and poorly differentiated adenocarcinomas was 2-4 times higher than that of moderately differentiated and signet-ring cell carcinomas, and was highly correlated with gastric fluid sialic acid (GSA) (r=0.72). It is suggested that the determination of gastric chymotrypsin not only has early diagnostic value but also relates to the degree of differentiation of gastric adenocarcinoma. It is a new non-protein marker for the diagnosis of gastric cancer.