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肝脏是体内糖脂代谢的重要器官,转录因子碳水化合物反应元件结合蛋白(ChREBP)是调节肝脏糖酵解及脂肪合成的重要转录因子。ChREBP与Max样蛋白X以异二聚体的形式调控葡萄糖利用及转化为脂肪过程中大量基因的表达。在ob/ob小鼠肝细胞特异性敲除ChREBP基因后能明显改善其脂肪肝及胰岛素抵抗。阐明ChREBP对糖脂代谢的调控机制及其生物学功能,可进一步解释葡萄糖诱导脂肪形成的过程,并有望为脂肪肝等代谢性疾病的干预治疗提供新的思路。本文对ChREBP的结构特征、调控机制、生物学功能及其与疾病的关系等最新进展进行综述。
The liver is an important organ for glycolipid metabolism. The transcription factor carbohydrate response element binding protein (ChREBP) is an important transcription factor that regulates hepatic glycolysis and adipogenesis. ChREBP and Max-Like Protein X Regulate the Expression of Large Numbers of Genes in the Formulation of Glucose Utilization and Conversion to Fat in the form of Heterodimers. Hepatic-specific knockout of ChREBP gene in ob / ob mouse can significantly improve its fatty liver and insulin resistance. To elucidate the regulatory mechanism and biological functions of ChREBP on glucose and lipid metabolism may further explain the process of glucose-induced adipogenesis and is expected to provide a new way of intervention for the treatment of metabolic diseases such as fatty liver. This review summarizes recent advances in the structural features, regulatory mechanisms, biological functions, and the relationship with ChREBP.