作为首选治疗、外科辅助治疗、同步放化疗、晚期和无法切除的头颈部恶性肿瘤的姑息治疗,放疗被大量地应用于头颈部肿瘤的治疗。尽管放疗能提高治愈率,但是,放疗也可导致许多副反应及后遗症,如黏膜炎、口腔干燥、味觉丧失、张口困难、龋齿、软组织坏死、放射性骨坏死(Osteoradionecrosis,ORN)等。ORN被认为是最严重的后遗症之一。拔除病变牙齿是颌骨ORN发生的主要危险因素。头颈部肿瘤病人放疗后拔牙会加大ORN发生的风险,这已成为共识。然而,放疗前拔牙会否增加ORN的发病率?相应的研究报道较少。因此,本文就头颈部肿瘤病人ORN的发生机制、放疗前拔牙术 As the preferred treatment, surgical adjuvant therapy, concurrent chemoradiotherapy, palliative treatment of advanced and unresectable head and neck malignancies, radiotherapy is widely used in the treatment of head and neck cancer. Radiation therapy can lead to many side effects and sequelae, such as mucositis, dry mouth, loss of taste, difficulty in opening mouth, dental caries, soft tissue necrosis, and osteonecrosis of the nose (ORT), although radiotherapy improves the cure rate. ORN is considered one of the worst sequelae. Removal of diseased teeth is the major risk factor for ORN in the jaw. Head and neck cancer patients after radiotherapy tooth extraction will increase the risk of ORN, it has become the consensus. However, pre-radiotherapy extraction will increase the incidence of ORN? Corresponding studies have reported less. Therefore, this article on the pathogenesis of ORN in patients with head and neck cancer, preoperative extraction of tooth extraction