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目的分析川崎病合并G6PD缺乏症患儿临床特点及转归。方法采用回顾性研究方法对本院2007年5月至2011年4月收治10例川崎病合并G6PD缺乏症患儿的临床表现、治疗反应和疾病转归进行分析。结果本组患儿均在起病10d内用丙种球蛋白治疗,潘生丁抗凝治疗6～8周,无1例发生冠脉扩张或冠状动脉瘤的形成。结论川崎病合并G6PD缺乏症患儿应用大剂量丙种球蛋白,潘生丁可防止冠脉扩张或冠状动脉瘤形成。
Objective To analyze the clinical characteristics and prognosis of children with Kawasaki disease complicated by G6PD deficiency. Methods The clinical manifestations, treatment response and disease outcomes of 10 Kawasaki disease patients with G6PD deficiency in our hospital from May 2007 to April 2011 were retrospectively studied. Results The patients were treated with gamma globulin within 10 days of onset and anticoagulant therapy with dipyridamole for 6-8 weeks. None of them developed coronary artery dilation or coronary aneurysm. Conclusion Kawasaki disease with G6PD deficiency in children with high doses of gamma globulin, dipyridamole can prevent coronary artery dilatation or coronary aneurysm formation.