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目的:通过高分辨率CT(HRCT)图像分析囊性纤维病(CF)患儿与正常儿童间是否存在气道结构差异。试验设计:获取肺完全膨胀及控制通气的状态的四维解剖水平的HRCT图像,研究对象包括34例CF患儿(年龄2.4±1.4岁)及20名正常对照儿童(年龄1.8±1.4 岁)。测量所有清晰可见的圆形通气管道的短轴直径以获取气道壁厚度(AWT),气道管腔内径(ALD)以及气道直径(VD)。结果:在CF组(x±s),AWT为0.58±0.13 mm,ALD为1.31±0.56 mm,VD为1.62±0.58 mm。在对照组:AWT为0.49±0.13 mm,ALD为1.07±0.42 mm,VD为1.86±0.64 mm。CF组的平均AWT及ALD
Objective: To analyze the existence of airway structure differences between children with cystic fibrosis (CF) and normal children by high resolution CT (HRCT) images. Experimental Design: Four-dimensional anatomical horizontal HRCT images of complete lung inflation and controlled ventilation were obtained from 34 patients with CF (age 2.4 ± 1.4 years) and 20 normal controls (age 1.8 ± 1.4 years). Measure the short axis diameter for all clearly visible circular ventilation lines for AWT, ALD and VD. Results: In CF group (x ± s), AWT was 0.58 ± 0.13 mm, ALD was 1.31 ± 0.56 mm, VD was 1.62 ± 0.58 mm. In the control group, the AWT was 0.49 ± 0.13 mm, the ALD was 1.07 ± 0.42 mm, and the VD was 1.86 ± 0.64 mm. Average AWT and ALD in CF group