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Objective: Foot injuries usually happen due to fatigue. Therefore,it is important to understand the changes of gait induced by foot fatigue. This paper aims to discuss the different changes of plantar pressure distribution (PPD) caused by fatigue after three different motions. Materials and Methods:The PPD of six healthy subjects were measured before and after speed steady running, shuttle running and speed agility running by the Footscan system. The peak force and contact time from ten plantar anatomical regions were calculated. Results:There was a significant difference in PPD between pre-and post-running. Furthermore, the changes of foot loading characteristics caused by fatigue in different motions were evidently distinct. Discussion:The possible reason may be the different fatigue degrees of muscles after different motions. It suggested that the effects of fatigue on gait in different motions must be considered to avoid sports injuries and different safeguard procedures should be taken in various motions to decrease the incidence of injuries induced by fatigue.