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目的建立新疆维吾尔自治区妇幼保健院新生儿疾病筛查中心实验室先天性甲状腺功能减低症筛查切值。方法以新疆地区部分助产机构出生的新生儿为筛查对象,于出生后72h,充分哺乳6次后采取足跟血,制成滤纸干血片,采用时间荧光分辨法检测标本中TSH浓度,进行统计分析。结果根据我中心检测76 549例新生儿TSH筛查的数据,确定新生儿疾病筛查中心实验室先天性甲状腺功能减低症的筛查切值为8.69μU/ml;结论新疆省妇幼保健院新生儿疾病筛查中心新制定的TSH参考切值筛查先天性甲状腺功能减低症具有可行性,为保证实验室工作质量提供了依据。
Objective To establish a cut-off value of congenital hypothyroidism (Hypothyroidism) screening test in neonatal screening center of MCH in Xinjiang Uygur Autonomous Region. Methods Newborns born in some midwifery institutions in Xinjiang were used as screening objects. After 72 hours of birth, they were fully breast-fed for 6 times and then heel-blood was taken to make dry pieces of filter paper. The concentration of TSH was detected by time- conduct statistical analysis. Results According to the data of 76 549 neonates examined by TSH in our center, the cut-off value of congenital hypothyroidism in neonatal screening center was 8.69μU / ml. Conclusion Neonates The screening of the TSH reference cut-off value of congenital hypothyroidism is feasible in the disease screening center, which provides a basis for ensuring the quality of laboratory work.