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目的分析中重度良性前列腺增生患者在手术前服用非那雄胺治疗的最佳时间。方法 90例中重度良性前列腺增生患者,随机分为A组、B组、C组,各30例,A组术前服用非那雄胺3个月以上(长疗程组),B组术前服用1周(短疗程组),C组术前未服用任何抗雄激素药物治疗(对照组),对比三组术中、术后各项指标。结果 A组在术中总出血量、术中冲洗液用量、手术时间及术后膀胱持续时间及术后冲洗液量同B组和C组对比,差异有统计学意义(P<0.05),B组除术后膀胱冲洗时间及术后冲洗液量同C组对比差异有统计学意义(P<0.05),其余各项指标差异无统计学意义(P>0.05)。结论对于中重度前列腺增生患者手术前服用非那雄胺3个月以上能够有效减少术中及术后出血,而短疗程服用1周减少出血效果不明显。
Objective To analyze the best time of finasteride treatment in patients with moderate to severe benign prostatic hyperplasia before operation. Methods Ninety patients with moderate to severe benign prostatic hyperplasia were randomly divided into group A, group B and group C, 30 cases each. Group A received finasteride for more than 3 months (long course group) before operation and group B 1 week (short course group), C group did not take any anti-androgen therapy before operation (control group), compared the three groups of intraoperative and postoperative indicators. Results The total amount of bleeding during operation, the volume of irrigating fluid, the time of operation, the duration of postoperative bladder and the amount of irrigating fluid after operation in group A were significantly different from those in group B and C (P <0.05) In addition to postoperative bladder washing time and postoperative washing fluid volume compared with the C group, the difference was statistically significant (P <0.05), the rest of the indicators showed no significant difference (P> 0.05). Conclusion For patients with moderate to severe benign prostatic hyperplasia before taking finasteride for more than 3 months can effectively reduce intraoperative and postoperative bleeding, and take a short course of treatment for 1 week to reduce the bleeding effect is not obvious.