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目的探讨苯巴比妥在预防新生儿缺氧缺血性脑病惊厥中的作用。方法115例新生儿缺氧缺血性脑病随机分为治疗组和对照组,均给予常规治疗。治疗组同时在入科6h内给予苯巴比妥15～20mg/kg静脉推注,分2次静脉推注,12h后给予维持量5mg/kg,共3～5d。结果治疗组57例出现惊厥8例,惊厥发生率为14.05%;对照组58例出现惊厥25例,惊厥发生率为43.10%,两组惊厥发生率差异有统计学意义(x2=11.87,P<0.005)。结论苯巴比妥预防新生儿缺氧缺血性脑病惊厥疗效显著,可明显降低惊厥发生,而且未见明显不良反应。
Objective To investigate the role of phenobarbital in the prevention of seizures in neonates with hypoxic-ischemic encephalopathy. Methods One hundred and fifteen neonates with hypoxic-ischemic encephalopathy were randomly divided into treatment group and control group, and were given routine treatment. At the same time, the treatment group was given intravenous bolus of pentobarbital 15 ~ 20mg / kg within 6h, divided into 2 intravenous injections, and maintained for 5 ~ 5d after 12h. Results In the treatment group, 57 cases had convulsions in 8 cases and the convulsions rate was 14.05%. In the control group, 58 cases had convulsions in 25 cases, the incidence of convulsion was 43.10%. There was significant difference in the incidence of convulsion between the two groups (x2 = 11.87, P < 0.005). Conclusion Phenobarbital is effective in preventing convulsion of neonatal hypoxic-ischemic encephalopathy. It can significantly reduce the incidence of convulsion and no obvious adverse reactions.