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目的探讨体外受精-胚胎移植(IVF-ET)患者妊娠结局的相关影响因素。方法回顾性分析618例首次实施常规体外受精(IVF)和卵母细胞浆内单精子显微注射(ICSI)的年轻且卵巢储备功能良好的不孕女性的临床资料。将临床诊断结果分为临床妊娠组和未临床妊娠组,进行单因素分析,将单因素分析有统计学差异的结果作为自变量,临床妊娠妊娠作为因变量,采用Logistic回归分析影响妊娠结局的相关因素。结果 618例患者平均年龄(28.81±3.55)岁,妊娠组为387例(62.6%),未妊娠组231例(37.4%)。单因素分析显示:妊娠组年龄小于未妊娠组,妊娠组h CG日子宫内膜厚度大于未妊娠组,妊娠组已移植胚胎质量高于未妊娠组(均P<0.05)。将单因素分析有差异的年龄、子宫内膜厚度、已移植胚胎质量进行Logistics回归分析,结果显示:年龄(OR=0.667,95%CI:0.512~0.869,P=0.030)、子宫内膜厚度(OR=1.251,95%CI:1.013~1.545,P=0.037)与临床妊娠结局相关。结论年轻且卵巢储备功能良好的女性首次IVF/ICSI中,年龄和子宫内膜厚度是成功的重要因素,年龄与妊娠结局成负相关,年龄越大越不容易妊娠,在适当范围内增加内膜厚度可提高妊娠率。
Objective To explore the influencing factors of pregnancy outcome in IVF-ET (IVF-ET). Methods The clinical data of 618 young infertile women with good ovarian reserve who underwent routine in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) of oocytes were retrospectively analyzed. The clinical diagnosis results were divided into clinical pregnancy group and non-clinical pregnancy group, univariate analysis, the univariate analysis of the results as a statistically significant independent variable, clinical pregnancy as a dependent variable, using Logistic regression analysis of pregnancy-related outcomes factor. Results The average age of 618 patients was 28.81 ± 3.55 years, 387 cases (62.6%) in pregnancy group and 231 cases (37.4%) in non-pregnancy group. Univariate analysis showed that the gestational age group was smaller than that of the non-pregnant group, and the CG endometrial thickness in pregnancy group was greater than that in the non-pregnant group. The quality of embryos transferred in the pregnancy group was higher than that in the non-pregnant group (all P <0.05). Logistic regression analysis showed that age (OR = 0.667,95% CI: 0.512-0.869, P = 0.030), endometrial thickness (P <0.05), endometrial thickness OR = 1.251, 95% CI: 1.013-1.545, P = 0.037) were associated with clinical pregnancy outcomes. Conclusions Age and endometrial thickness among young women with good ovarian reserve function are the important factors of success in the first IVF / ICSI. Age is negatively correlated with the outcome of pregnancy. The older the older, the less likely to be pregnant. The thickness of the intima increases within the appropriate range Can improve the pregnancy rate.